- Creatine supplementation improved physical (strength endurance) and prolonged cognitive (Stroop accuracy) performance.
- Creatine supplementation had no effect on short sport-specific psychomotor or cognitive (Flanker) performance, nor did it have any effect on the mental fatigue-induced reduction in performance on these tasks.
- The improved prolonged cognitive performance indicates that creatine supplementation might be able to partially counteract the mental fatigue-induced reduction in performance.
- From a practical point of view, these results indicate that further research into the possible role of creatine supplementation in countering mental fatigue-induced performance reductions in long-term tasks (e.g. a 90-min football match) is warranted.
- From a mechanistic point of view, these results suggest a possible role for brain phosphocreatine in mental fatigue.
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